A CHROMATOGRAPHIC METHOD FOR THE DETECTION OF TRYPTOPHAN METABOLITES
نویسندگان
چکیده
منابع مشابه
A chromatographic method for the detection of tryptophan metabolites.
During the course of investigations involving the action of tissue slices on tryptophan, the aqueous medium in which n-kynurenine sulfate had been incubated with kidney slices was found to have acquired a marked bluish violet fluorescence. Subsequent investigation showed that several known metabolites of tryptophan fluoresce when suitably exposed to ultraviolet light. Advantage has been taken o...
متن کاملChromatographic analysis of tryptophan metabolites
The kynurenine pathway generates multiple tryptophan metabolites called collectively kynurenines and leads to formation of the enzyme cofactor nicotinamide adenine dinucleotide. The first step in this pathway is tryptophan degradation, initiated by the rate-limiting enzymes indoleamine 2,3-dioxygenase, or tryptophan 2,3-dioxygenase, depending on the tissue. The balanced kynurenine metabolism, w...
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Neurotoxicity of tryptophan metabolites.
The metabolism of tryptophan by the kynurenine pathway leads to the production of several neurotoxic compounds, some of which have been associated with neurological disorders. Recent investigation of some relevant compounds in this pathway has provided further evidence of their neurotoxicity.
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1951
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)77752-7